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Mapping Data
Experiment
  • Experiment
    TEXT-QTL
  • Chromosome
    7
  • Reference
    J:82018 Adarichev VA, et al., Combined autoimmune models of arthritis reveal shared and independent qualitative (binary) and quantitative trait loci. J Immunol. 2003 Mar 1;170(5):2283-92
  • ID
    MGI:2656601
Genes
GeneAlleleAssay TypeDescription
Pgia21 visible phenotype
D7Mit62 SSLP
Notes
  • Experiment
    135 SSLP markers were screened in a set of 939 (BALB/cCrl x DBA/1J)F2 intercross animals to identify QTLs associated with collagen-induced arthritis (CIA) and proteoglycan-induced arthritis (PGIA). Parental strain BALB/cCrl is CIA-resistant and PGIA-susceptible while parental strain DBA/1J is CIA-susceptible and PGIA-resistant.

    A major locus was identified on mouse Chromosome 17 in linkage to both CIA (LOD=21) and PGIA (LOD=6). This locus, Pgia17, has been previously identified and maps to proximal Chromosome 17.

    Pgia21, a novel locus associated with PGIA, maps to mouse Chromosome 7 at approximately 43 cM with peak marker D7Mit62. Pgia21 is linked to IL-2 production (LOD=8.1).

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory