Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:82018 Adarichev VA, et al., Combined autoimmune models of arthritis reveal shared and independent qualitative (binary) and quantitative trait loci. J Immunol. 2003 Mar 1;170(5):2283-92
• ID
  MGI:2656595

Genes

Gene	Assay Type
Pgia19	visible phenotype
D6Mit223	SSLP
D6Mit9	SSLP

Notes

• Experiment
  135 SSLP markers were screened in a set of 939 (BALB/cCrl x DBA/1J)F2 intercross animals to identify QTLs associated with collagen-induced arthritis (CIA) and proteoglycan-induced arthritis (PGIA). Parental strain BALB/cCrl is CIA-resistant and PGIA-susceptible while parental strain DBA/1J is CIA-susceptible and PGIA-resistant.
  
  A major locus was identified on mouse Chromosome 17 in linkage to both CIA (LOD=21) and PGIA (LOD=6). This locus, Pgia17, has been previously identified and maps to proximal Chromosome 17.
  
  Pgia19, a novel locus associated with PGIA, maps to mouse Chromosome 6 to an interval spanning 19cM - 37cM, flanked by markers D6Mit223 and D6Mit9. Pgia19 is linked to soluble CD44 production (LOD=4.5), arthritis score (LOD=2.9), onset (LOD=3.1) and susceptibility (LOD=3.4).