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Mapping Data
Experiment
  • Experiment
    TEXT-QTL
  • Chromosome
    7
  • Reference
    J:71973 Tripodis N, et al., Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome. J Natl Cancer Inst. 2001 Oct 3;93(19):1484-91
  • ID
    MGI:2387386
Genes
GeneAlleleAssay TypeDescription
Sluc19 resistance/susceptibility
D7Mit105
Sluc30 resistance/susceptibility
D7Mit57
Notes
  • Experiment
    Several F2 crosses between inbred strain O20/A and recombinant congenic strains OcB-3/Dem, OcB-4/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem were used to map QTLs linked to lung tumor susceptibility. Parental strain O20/A and OcB-4/Dem are susceptible to lung tumor development after ENU treatment whereas parental strains OcB-3/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem are relatively resistant. 14 previously identified lung tumor susceptibility loci were detected in these crosses (Sluc1-Sluc14) and 16 new loci were identified with a statistical significance of P>0.05. All of the QTL were detected in pairwise interactions, Table 1, Fig 1.

    In the (OcB16 x O20/A)F2 cross newly identified QTL Sluc19 mapped to Chr 7 in linkage with D7Mit105 at approximately 63.5 cM.

    In the (OcB3 x O20/A)F2 cross newly identified Sluc30 mapped to mouse Chr 7 in linkage with D7Mit57 at approximately 4 cM.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory