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Mapping Data
Experiment
  • Experiment
    TEXT-QTL
  • Chromosome
    7
  • Reference
    J:50828 Klein RF, et al., Quantitative trait loci affecting peak bone mineral density in mice. J Bone Miner Res. 1998 Nov;13(11):1648-56
  • ID
    MGI:2149383
Genes
GeneAlleleAssay TypeDescription
Bomd1 visible phenotype
D7Mit234a
Igf1r reported elsewhere
Pth reported elsewhere
Calca reported elsewhere
Notes
  • Experiment
    24 BXD RI (recombinant inbred) strains were analyzed for loci associated with bone mineral density (BMD) and body weight in 12-week-old female animals. Progenitor strain C57BL/6 exhibits greater bone mass than progenitor strain DBA/2 at 84 days of age, but body weight is very similar between the 2 strains. After screening over 1500 informative markers on a BXD mapping panel 10 provisional QTLs associated with BMD mapped to 9 different chromosomes and await confirmation. Two of the most significant BMD QTLs (P = 0.0007), Bomd1, mapped to mouse chromosome 7 at 44 cM (in linkage with D7Mit234a), and Bomd2, mapped to mouse Chromosome 14 at 2 cM (in linkage with Ptprg). Possible candidate genes for Bomd1 are the insulin-like growth factor I receptor (Igf1r), parathyroid hormone (Pth), and calcitonin (Calca, previously Ct). A possible candidate gene for Bomd2 is bone morphogenetic protein 4 (Bmp4).

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory