Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  7
• Reference
  J:63761 Beckers J, et al., The mouse rib-vertebrae mutation disrupts anterior-posterior somite patterning and genetically interacts with a delta1 null allele. Mech Dev. 2000 Jul;95(1-2):35-46
• ID
  MGI:1889654

Genes

Gene	Assay Type	Description
D7Mit253	PCR amplified length variant
D7Mit166	PCR amplified length variant
D7Mit66	PCR amplified length variant
D7Mit165	PCR amplified length variant
D7Mit206	PCR amplified length variant
D7Mit9	PCR amplified length variant
D7Mit358	PCR amplified length variant
Tbx6	visible phenotype
D7Mit164	PCR amplified length variant
D7Mit188	PCR amplified length variant
D7Mit105	PCR amplified length variant
Mesp1	reported elsewhere
Mesp2	sequence analysis	Mesp2 cDNA

Notes

• Experiment
  Initial mapping using intercross and backcross progeny placed rv between D7Mit253 and D7Mit165. The interval was further reduced to to a region flanked by D7Mit66 and D7Mit165.
  212 (Stock-rv/rv x CAST/Ei)F1 X (Stock-rv/rv x CAST/Ei)F1 intercross mice were informative to provide the following order of loci on mouse Chromosome 7: D7Mit66 - 2.36 +/- 74 cM - D7Mit206 - D7Mit9 - D7Mit358 - 0.23 +/- 0.24 cM - rv - D7Mit188 - 0.23 +/- 0.24 cM - D7Mit105 - 0.94 +/- 0.47 cM - D7Mit165. Moreover, 283 (Stock-rv/rvx CAST/Ei)F1 x Stock-rv/rv backcross mice were informative to provide the following order of loci on mouse Chromosome 7: D7Mit66 -4.24 +/- 1.2 - cM D7Mit206 - D7Mit9 - D7Mit358 - 1.06 +/- 0.61 cM - rv - D7Mit164 - 0.71 +/- 0.5 cM - D7Mit188 - 0.35 +/- 0.35 cM - D7Mit105 0.35 +/- 0.35 cM - D7Mit165. The authors indicated that markers Mesp1 and Mesp2 are excluded as candidates for the rv mutation.