Mapping Data

Experiment

• Experiment
  TEXT-Physical Mapping
• Chromosome
  4
• Reference
  J:50117 Morgan D, et al., Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse. (Erratum appears in v. 20, pg. 312). Nat Genet. 1998 Oct;20(2):149-56
• ID
  MGI:1344465

Genes

Gene	Assay Type	Description
Invs	overlapping clones, direct sequencing	394-P2
Tex10	overlapping clones	394-P2
Hnrpfl	overlapping clones	394-P2

Notes

• Experiment
  The authors used phenotype rescue studies and identified a 47kb deletion on mouse Chromosome 4 responsible for the inv mutant phenotype. The Invs gene was present in the deleted region. Analysis of the BAC/YAC contig spanning the region revealed the presence of the Hnrpfl gene at the telomeric end of the BAC 394-P2 while the Tex10 gene (identified by the clone 18330) was located at a position centromeric to the inv deletion. Both the Tex10 as well as the Hnrpfl gene are transcribed in homozygous inv mice.