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Inbred Strains of Mice: BPH

BPH /2

Inbr (J, 1998) F55. Albino. Gunther Schlager, U. of Kansas. Genetic selection for high blood pressure initiated in 1966 from a base population derived from an 8-way cross among LP/J, SJL/J, BALB/cJ, C57BL/J, 129/J, CBA/J, RF/J and BDP/J. Inbreeding avoided until F23 when several inbred substrains were initiated. Strain has a high systolic blood pressure, shortened life span, low norephinephrine content in whole brain, larger relative heart and kidney weight, fewer glomeruli in the kidney and larger 24-hr. urinary volume Schlager (1974, 1981,1994) (see also BPL). Maintained by J.

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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