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Phenotype Images associated with this Allele
Nomenclature
Symbol: Qsox1b2b2673Clo
Name: quiescin Q6 sulfhydryl oxidase 1; Bench to Bassinet Program (B2B/CVDC) mutation 2673, Cecilia Lo
MGI ID: MGI:5615575
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant (E16.5) exhibits persistent truncus arteriosis (PTA) which was confirmed by ECM histopathology.Qsox1b2b2673Clo/Qsox1b2b2673CloC57BL/6J-Qsox1b2b2673Clo
Mutant (E16.5) shows hypoplastic thymus and malrotated heart.Qsox1b2b2673Clo/Qsox1b2b2673CloC57BL/6J-Qsox1b2b2673Clo
EFIC SummaryQsox1b2b2673Clo/Qsox1b2b2673CloC57BL/6J-Qsox1b2b2673Clo
Serial 2D ECM stack of mutant in the coronal plane reveals persistent truncus arteriosis (PTA), atrioventricular septal defect (AVSD), tracheoesophageal fistula, aberrant subclavian artery forming incomplete vascular ring, left atrial isomerism, and biventricular hypertrophy.
Click thumbnail to play movie.
Qsox1b2b2673Clo/Qsox1b2b2673CloC57BL/6J-Qsox1b2b2673Clo
Mutant (E16.5) presents with micropthalmia, short snout, microganthia, and preaxial digit duplication.Qsox1b2b2673Clo/Qsox1b2b2673CloC57BL/6J-Qsox1b2b2673Clo
Mutant (E16.5) exhibits a hypoplastic thymusQsox1b2b2673Clo/Qsox1b2b2673CloC57BL/6J-Qsox1b2b2673Clo
Mutant (E16.5) presents with a hypoplastic spleenQsox1b2b2673Clo/Qsox1b2b2673CloC57BL/6J-Qsox1b2b2673Clo
EFIC SummaryQsox1b2b2673Clo/Qsox1b2b2673CloC57BL/6J-Qsox1b2b2673Clo
Serial 2D ECM stack of mutant (ED16.5) in the coronal plane reveals atrioventricular septam defect (AVSD) with dual inferior vena cava (IVC).
Click thumbnail to play movie.
Qsox1b2b2673Clo/Qsox1b2b2673CloC57BL/6J-Qsox1b2b2673Clo
Mutant (E16.5) presents with hydrops, petechiae, bilateral anopthalmia, agnathia, and short snoutQsox1b2b2673Clo/Qsox1b2b2673CloC57BL/6J-Qsox1b2b2673Clo

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory