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Phenotype Images associated with this Allele
Nomenclature
Symbol: Adamts6b2b2182Clo
Name: ADAM metallopeptidase with thrombospondin type 1 motif 6; Bench to Bassinet Program (B2B/CVDC), mutation 2182 Cecilia Lo
MGI ID: MGI:5491254
Synonyms: Heimlich
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2182-003-1 (E15.5) has a dilated pulmonary artery and an overriding aorta diagnosed by EFIC imagingAdamts6b2b2182Clo/Adamts6b2b2182CloC57BL/6J-Adamts6b2b2182Clo
EFIC SummaryAdamts6b2b2182Clo/Adamts6b2b2182CloC57BL/6J-Adamts6b2b2182Clo
Serial 2D EFIC image stack in the coronal plane of 2182-003-1 (E15.5) shows overriding aorta, AVSD, and biventricular hypertrophy
Click thumbnail to play movie.
Adamts6b2b2182Clo/Adamts6b2b2182CloC57BL/6J-Adamts6b2b2182Clo
Mutant 2182-003-1 (E15.1) presents with abnormally attached hindlimbs, short snout, dome-shaped head, micrognathia, and slight hydropsAdamts6b2b2182Clo/Adamts6b2b2182CloC57BL/6J-Adamts6b2b2182Clo
Mutant 2182-003-1 (E15.5) exhibits a hypoplastic thymusAdamts6b2b2182Clo/Adamts6b2b2182CloC57BL/6J-Adamts6b2b2182Clo
Mutant 2182-003-2 (E15.5) presents with abnormally attached hindlimbs, short snout, dome-shaped head, and slight hydropsAdamts6b2b2182Clo/Adamts6b2b2182CloC57BL/6J-Adamts6b2b2182Clo
Mutant 2182-003-2 (E15.5) has a cleft palateAdamts6b2b2182Clo/Adamts6b2b2182CloC57BL/6J-Adamts6b2b2182Clo
Mutant 2182-003-2 (E15.5) shows a hypoplastic thymusAdamts6b2b2182Clo/Adamts6b2b2182CloC57BL/6J-Adamts6b2b2182Clo
Mutant 2182-003-2 (E15.5) exhibits malaligned great arteries, and shown to have DORV by EFIC imagingAdamts6b2b2182Clo/Adamts6b2b2182CloC57BL/6J-Adamts6b2b2182Clo
EFIC SummaryAdamts6b2b2182Clo/Adamts6b2b2182CloC57BL/6J-Adamts6b2b2182Clo
Serial 2D EFIC image stack in the coronal plane of 2182-003-2 (E15.5) exhibits DORV, AVSD, and biventricular hypertrophy
Click thumbnail to play movie.
Adamts6b2b2182Clo/Adamts6b2b2182CloC57BL/6J-Adamts6b2b2182Clo

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory