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Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b2012.2Clo
Name: Mutant line 2012.2; Bench to Bassinet Program (B2B/CVDC), mutation 2012, subline 2 Cecilia Lo
MGI ID: MGI:5491233
Synonyms: Cyclops
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant exhibits biventricular hypertrophy.b2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.2Clo/b2b2012.2CloC57BL/6J-b2b2012.2Clo
EFIC Summaryb2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.2Clo/b2b2012.2CloC57BL/6J-b2b2012.2Clo
Serial 2D ECM image stack in the coronal plane of mutant shows biventricular hypertrophy.
Click thumbnail to play movie.		b2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.2Clo/b2b2012.2CloC57BL/6J-b2b2012.2Clo
Mutant has cyclopia.b2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.2Clo/b2b2012.2CloC57BL/6J-b2b2012.2Clo
Mutant shows a proboscis, no mouth opening, agnathia, and low-set ears.b2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.2Clo/b2b2012.2CloC57BL/6J-b2b2012.2Clo
Mutant has a right aortic arch which was confirmed by ECM imaging.b2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.2Clo/b2b2012.2CloC57BL/6J-b2b2012.2Clo
EFIC Summaryb2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.2Clo/b2b2012.2CloC57BL/6J-b2b2012.2Clo
Serial 2D ECM image stack in the coronal plane of mutant shows right aortic arch and biventricular hypertrophy.
Click thumbnail to play movie.		b2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.2Clo/b2b2012.2CloC57BL/6J-b2b2012.2Clo
Serial 2D micro-CT image stack in the coronal plane of mutant reveals right aortic arch (RAA), holoprosencephaly, craniofacial dysplasia, and bilateral anophthalmia.
Click thumbnail to play movie.		b2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.2Clo/b2b2012.2CloC57BL/6J-b2b2012.2Clo
Mutant shows micrognathia and enopthalmia of the left eye.b2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.2Clo/b2b2012.2CloC57BL/6J-b2b2012.2Clo
Mutant has anopthalmia of the right eye and micrognathia.b2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.2Clo/b2b2012.2CloC57BL/6J-b2b2012.2Clo
Mutant exhibits biventricular hypertrophy.b2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.2Clo/b2b2012.2CloC57BL/6J-b2b2012.2Clo
EFIC Summaryb2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.2Clo/b2b2012.2CloC57BL/6J-b2b2012.2Clo
Serial 2D ECM image stack in the coronal plane of mutant shows biventricular hypertrophy.
Click thumbnail to play movie.		b2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.2Clo/b2b2012.2CloC57BL/6J-b2b2012.2Clo
Mutant exhibits anopthalmia and micrognathia with a facial cleft.b2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.2Clo/b2b2012.2CloC57BL/6J-b2b2012.2Clo
Mtuant shows a short snout and anopthalmiab2b2012Clo/b2b2012CloC57BL/6J-b2b2012Clo
b2b2012.2Clo/b2b2012.2CloC57BL/6J-b2b2012.2Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory