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Phenotype Images associated with this Allele
Nomenclature
Symbol: Drc1b2b1654Clo
Name: dynein regulatory complex subunit 1; Bench to Bassinet Program (B2B/CVDC), mutation 1654 Cecilia Lo
MGI ID: MGI:5438062
Synonyms: Aardvark, Ccdc164b2b1654Clo
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1654-002-MNA displays levocardia with dual hepatic veinDrc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
EFIC SummaryDrc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
Serial 2D EFIC image stack of 1654-002-MNC in the coronal plane reveals levocardia, bilateral hepatic vein and azygous connection
Click thumbnail to play movie.		Drc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
Serial 2D micro-MRI image stack in the coronal plane of 1654-002-MNA reveals heterotaxy with levocardia and dextrogastria, bilateral hepatic vein and azygous venous connection, ambiguous atrium, right lung isomerism
Click thumbnail to play movie.		Drc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
Mutant 1654-002-MNA presents with micrognathiaDrc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
Mutant 1654-002-MNA presents with malaligned sternal vertebraDrc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
Mutant 1654-002-MNA displays dextrogastria with malformed spleenDrc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
Mutant 1654-003-LA displays heterotaxy indicated by dextrocardia with levogastriaDrc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
Mutant 1654-003-LA displays dextrocardiaDrc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
EFIC SummaryDrc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
Serial 2D EFIC image stack of 1654-003-LA in the coronal plane reveals mirror image dextrocardia {I,L,I}
Click thumbnail to play movie.		Drc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
Videomicroscopy of mutant 1654-003-LA reveals dyskinetic airway cilia
Click thumbnail to play movie.		Drc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
Mutant 1654-007-LA displays heterotaxy indicated by dextrocardia with inverted liver lobation, left-sided pancreas and spleen, right-sided stomachDrc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
EFIC SummaryDrc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
Serial 2D EFIC image stack of 1654-007-LA in the coronal plane reveals mirror image dextrocardia
Click thumbnail to play movie.		Drc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
Mutant 1654-007-LA displays left-sided pancreas and spleen and right-sided stomachDrc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
Videomicroscopy of mutant 1654-007-LA airway reveals dyskinetic and immotile cilia
Click thumbnail to play movie.		Drc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
Mutant 1654-005-1 exhibits dextrocardia with dual IVC and parallel outflow tracts, which is confirmed as TGA by EFIC imagingDrc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
EFIC SummaryDrc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
Serial 2D EFIC image stack of 1654-005-1 (E15.5) in the coronal plane reveals heterotaxy, dextrocardia, TGA {A,L,L}, AVSD, interrupted aortic arch (type-b), bilateral IVS, left bronchial isomerism
Click thumbnail to play movie.		Drc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
Mutant 1654-005-1 has asplenia and left liver isomerism with a right-sided stomach and pancreasDrc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
Mutant 1625-025-LA exhibits situs inversus totalis, which is indicated by dextrocardia and dextrogastriaDrc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
EFIC SummaryDrc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
Serial 2D EFIC image stack in the coronal plane of 1624-025-LA reveals mirror image dextrocardia {I,L,L}
Click thumbnail to play movie.		Drc1b2b1654Clo/Drc1b2b1654CloC57BL/6J-Drc1b2b1654Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory