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Phenotype Images associated with this Allele
Nomenclature
Symbol: Dnah5b2b1537Clo
Name: dynein, axonemal, heavy chain 5; Bench to Bassinet Program (B2B/CVDC), mutation 1537 Cecilia Lo
MGI ID: MGI:5433326
Synonyms: T-Rex
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1537-002-LA displays heterotaxy associated with dextrocardia, dual IVC and mirror symmetric lung lobationDnah5b2b1537Clo/Dnah5b2b1537CloC57BL/6J-Dnah5b2b1537Clo
Mutant 1537-002-LA displays dextrocardia with mirror symmetric lung and liver lobationDnah5b2b1537Clo/Dnah5b2b1537CloC57BL/6J-Dnah5b2b1537Clo
EFIC SummaryDnah5b2b1537Clo/Dnah5b2b1537CloC57BL/6J-Dnah5b2b1537Clo
Serial 2D EFIC image stack in the coronal plane of 1537-002-LA reveals mirror image dextrocardia and dual IVC
Click thumbnail to play movie.		Dnah5b2b1537Clo/Dnah5b2b1537CloC57BL/6J-Dnah5b2b1537Clo
Mutant 1537-002-LA has immotile airway cilia
Click thumbnail to play movie.		Dnah5b2b1537Clo/Dnah5b2b1537CloC57BL/6J-Dnah5b2b1537Clo
Mutant 1537-004-LA shows dextrocardia with right aortic arch, left sided IVC, and reversed lung lobationDnah5b2b1537Clo/Dnah5b2b1537CloC57BL/6J-Dnah5b2b1537Clo
Mutant 1537-004-LA displays dextrocardia with reversed lung and liver lobationDnah5b2b1537Clo/Dnah5b2b1537CloC57BL/6J-Dnah5b2b1537Clo
Mutant 1537-004-LA exhibits dextrocardia with mirror symmetric lung lobation and right sided stomach and spleen indicative of situs inversus totalisDnah5b2b1537Clo/Dnah5b2b1537CloC57BL/6J-Dnah5b2b1537Clo
Videomicroscopy of 1537-004-LA airway reveals immotile cilia
Click thumbnail to play movie.		Dnah5b2b1537Clo/Dnah5b2b1537CloC57BL/6J-Dnah5b2b1537Clo
Videomicroscopy of 1537-004-LA tracheal airway epithelia reveals immotile cilia
Click thumbnail to play movie.		Dnah5b2b1537Clo/Dnah5b2b1537CloC57BL/6J-Dnah5b2b1537Clo
Mutant 1537-004-LC shows dextrocardia with reversal of lung, stomach, liver situs indicative of situs inversus totalis.Dnah5b2b1537Clo/Dnah5b2b1537CloC57BL/6J-Dnah5b2b1537Clo
Mutant 1537-004-LC shows reversal of kidney situsDnah5b2b1537Clo/Dnah5b2b1537CloC57BL/6J-Dnah5b2b1537Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory