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Phenotype Images associated with this Allele
Nomenclature
Symbol: Tab1b2b449Clo
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1; Bench to Bassinet Program (B2B/CVDC), mutation 449 Cecilia Lo
MGI ID: MGI:5314079
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
2D serial EFIC image stack in the coronal view of mutant 449-005-2 (ED16.5) reveals PTA type-I
Click thumbnail to play movie.		Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Mutant 449-005-2 (E16.5) exhibit persistent truncus arteriosus (PTA), which was confirmed by EFIC analysis.Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
2D serial EFIC image stack in the coronal view of mutant 449-005-1 (ED16.5) reveals DORV {SDD}, subaortic VSD, and interrupted aortic arch type-B
Click thumbnail to play movie.		Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Mutant 449-005-1 (E16.5) exhibit interrupted aortic arch (IAA) and malalignment of the great arteries, which was shown to be double outlet right ventricle (DORV) by EFIC analysis.Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
2D serial EFIC image stack in the coronal plane of newborn mutant 449-002-NA reveals DORV {SDD}, suboaortic VSD, Interrupted aortic arch type-B, and high take-off right coronary artery
Click thumbnail to play movie.		Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Newborn mutant 449-002-NA exhibit interrupted aortic arch (IAA) and malalignment of the great arteries, confirmed as double outlet right ventricle (DORV) by EFIC analysis.Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
2D serial EFIC image stack in the coronal plane of newborn mutant 449-003-NB (ED21.5) reveals DORV {SDD}, subaortic VSD, ASD (II), and vascular sling.
Click thumbnail to play movie.		Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
2D imaging of mutant 449-006-6 (E17.5) in transverse view showed atrioventricular septal defect (AVSD)
Click thumbnail to play movie.		Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Color flow imaging of mutant 449-006-6 (E17.5) in transverse view showed infow tract regurgitation at endocardial cushion level suggesting atrioventricular septal defect (AVSD).Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Color flow imaging of mutant 449-006-6 (E17.5) in transverse view showed infow tract forward flow and regurgitation at endocardial cushion level suggesting atrioventricular septal defect (AVSD).
Click thumbnail to play movie.		Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Color flow imaging of mutant 449-006-6 in transverse view showed infow tract forward flow at endocardial cushion level which indicates AVSDTab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Spectral Doppler of mutant 449-006-6 (E17.5) showed inflow tract regurgitation (R).Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Color flow imaging of mutant 449-006-6 (E17.5) in sagittal view showed single outflow originating from the right ventricle (RV) with regurgitation, and a large VSD indicating persistent truncus arteriousus (PTA).
Click thumbnail to play movie.		Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Color flow imaging of mutant 449-006-6 (E17.5) in sagittal view showed single outflow originating from the right ventricle (RV) and a large VSD indicating persistent truncus arteriosus (PTA).Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Color flow imaging of mutant 449-006-6 (E17.5) in sagittal view showed single outflow originating from the right ventricle with regurgitation, a large VSD, and persistent truncus arteriosus (PTA).Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Mutant 449-006-6 (E17.5) with interrupted aortic arch (IAA) and persistent truncus arteriosus (Van Praagh type A4) confirmed by EFIC analysis.Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
Tab1b2b449Clo/Tab1b2b449CloC57BL/6J-Tab1b2b449Clo
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory