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Phenotype Images associated with this Allele
Nomenclature
Symbol: Prkar1atm1.2Lsk
Name: protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1.2, Lawrence Kirschner
MGI ID: MGI:3512112
Synonyms: Prkar1aloxP
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Prkar1a heterozygosity accelerates osteosarcoma development in Tg(Bglap2-TAg)1Rkho/0 micePrkar1atm1.2Lsk/Prkar1a+
Tg(Bglap2-TAg)1Rkho/0
Tg(Col1a1-cre)1Kry/0		involves: 129S1/Sv * 129X1/SvJ * FVB/N
Tg(Bglap2-TAg)1Rkho/0FVB/N-Tg(Bglap2-TAg)1Rkho
Bone tumorigenesis nd abundant osteoclasts in Prkar1atm1.2Lsk/Prkar1a+ Tg(Col1a1-cre)1Kry/0 micePrkar1atm1.2Lsk/Prkar1a+
Tg(Bglap2-TAg)1Rkho/0
Tg(Col1a1-cre)1Kry/0		involves: 129S1/Sv * 129X1/SvJ * FVB/N
Tg(Bglap2-TAg)1Rkho/0FVB/N-Tg(Bglap2-TAg)1Rkho
Prkar1atm1.2Lsk/Prkar1a+
Tg(Col1a1-cre)1Kry/0		involves: 129S1/Sv * 129X1/SvJ * FVB/N
Osteosarcoma characterization in Tg(Bglap2-TAg)1Rkho/0 and Prkar1atm1.2Lsk/Prkar1a+ Tg(Col1a1-cre)1Kry/0 Tg(Bglap2-TAg)1Rkho/0 micePrkar1atm1.2Lsk/Prkar1a+
Tg(Bglap2-TAg)1Rkho/0
Tg(Col1a1-cre)1Kry/0		involves: 129S1/Sv * 129X1/SvJ * FVB/N
Tg(Bglap2-TAg)1Rkho/0FVB/N-Tg(Bglap2-TAg)1Rkho
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory