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Phenotype Images associated with this Allele
Nomenclature
Symbol: Dsg3tm1Stan
Name: desmoglein 3; targeted mutation 1, John R Stanley
MGI ID: MGI:1857388
Synonyms: Dsg3-
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Dsg3tm1Stan/Dsg3tm1Stan mice are runts and have skin erosions and eye lesionsDsg3tm1Stan/Dsg3tm1Staninvolves: 129X1/SvJ * C57BL/6J
Oral and skin lesions in Dsg3tm1Stan/Dsg3tm1Stan mice compared to skin lesions in human Pemphigus Vulgaris patientsDsg3tm1Stan/Dsg3tm1Staninvolves: 129X1/SvJ * C57BL/6J
Ultrastructure of lesional posterior lingual epithelium in Dsg3tm1Stan/Dsg3tm1Stan miceDsg3tm1Stan/Dsg3tm1Staninvolves: 129X1/SvJ * C57BL/6J
Balding phenotype of Dsg3tm1Stan/Dsg3tm1Stan mice (lower) compared to littermate control (upper)Dsg3tm1Stan/Dsg3tm1Staninvolves: 129X1/SvJ * C57BL/6J
Oral mucosal blister in Dsg3tm1Stan/Dsg3tm1Stan mouse shows suprabasilar acantholysisDsg3tm1Stan/Dsg3tm1Staninvolves: 129X1/SvJ * C57BL/6J
Balding Dsg3tm1Stan/Dsg3tm1Stan mice exhibit slightly cystic telogen hair follicles that lack a hair shaftDsg3tm1Stan/Dsg3tm1Staninvolves: 129X1/SvJ * C57BL/6J
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory