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| Caption | The number of melanocyte (MC) lineage cells is dramatically reduced by MC lineage-specific knock out of RBP-J. (A-F) Coat-color phenotype of a Tg(Tyr-cre)#Lru/0 Rbpjtm1Hon/Rbpjtm1Hon (Tyr-Cre;RBP-Jf/f) mouse. P4 (A), P18 (B), and P32 (C) Tg(Tyr-cre)#Lru/0 Rbpjtm1Hon/Rbpjtm1Hon mice with their control littermates are shown. Hairs from a P18 Tg(Tyr-cre)#Lru/0 Rbpjtm1Hon/Rbpj+ (Tyr-Cre;RBP-J+/f) mouse (D) are fully pigmented, whereas hairs from a P18 Tg(Tyr-cre)#Lru/0 Rbpjtm1Hon/Rbpjtm1Hon mouse (E) are a mixture of pigmented and unpigmented. Hairs grown in the next hair cycle from a P32 Tg(Tyr-cre)#Lru/0 Rbpjtm1Hon/Rbpjtm1Hon mouse (C, shaved area; and F) are almost all unpigmented compared with the mixture of the primary and secondary hairs (C, unshaved area). (G-I) Immunofluorescent staining of P4 skin using anti-Dct (green) antibody. Skin from wild-type (WT; G), Tg(Tyr-cre)#Lru/0 Rbpjtm1Hon/Rbpj+ (H), and Tg(Tyr-cre)#Lru/0 Rbpjtm1Hon/Rbpjtm1Hon mutant (I) mice are shown. Arrowheads indicate MCs in the hair follicle (HF). (J-M) Whole-mount staining of dorsal skin epidermis from E16.5 (J and K) and P0 (L and M) mice using anti-c-Kit antibody. Epidermis obtained from a Tg(Tyr-cre)#Lru/0 Rbpjtm1Hon/Rbpj+ (J and L) or a Tg(Tyr-cre)#Lru/0 Rbpjtm1Hon/Rbpjtm1Hon mouse (K and M) is shown. | ||||||
| Copyright | This image is from Moriyama M, J Cell Biol 2006 May 8;173(3):333-9, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:111228 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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