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Phenotype Image Detail
Image
Caption Wdfy3tm1a(KOMP)Mbp/Wdfy3tm1a(KOMP)Mbp mice generated through gene targeting exhibit more severe neurodevelopmental defects than Wdfy3disc/Wdfy3disc mice. (a) Nissl stained coronal hemisections through the forebrains of wild-type (WT), heterozygous and homozygous lacZ newborn pups illustrate the malformations present in affected mutants. The yellow dashed line indicates the cortical length in the WT as measured from the corticostriatal boundary to the ventricular apex. The red dashed line indicates differences in cortical length present in the lacZ mutants. (b) Close-ups of cortical segments of lateral and dorsal positions demonstrate cortical thinning in lacZ mutants.
Copyright This image is from Orosco LA, Nat Commun 2014;5():4692, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:225200
Associated
Alleles
Symbol Name
Wdfy3tm1a(KOMP)Mbp WD repeat and FYVE domain containing 3; targeted mutation 1a, Mouse Biology Program, UCDavis
Wdfy3tm1a(KOMP)Mbp WD repeat and FYVE domain containing 3; targeted mutation 1a, Mouse Biology Program, UCDavis
Associated
Genotypes
Allelic Composition Genetic Background
Wdfy3tm1a(KOMP)Mbp/Wdfy3tm1a(KOMP)Mbp C57BL/6N-Wdfy3tm1a(KOMP)Mbp

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/16/2019
MGI 6.13
The Jackson Laboratory