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Phenotype Image Detail
Image
Caption Postnatal lethality by P5, with arteriovenous malformations (AVMs) in the brain, lung, and GI tract of Acvrl1tm2.1Spo/Acvrl1tm2.1Spo Tg(Acvrl1-cre)L1Spo/0 mice. (A-E) Dissection microscopic views of vascular images of control (A and C) and mutant Acvrl1tm2.1Spo/Acvrl1tm2.1Spo Tg(Acvrl1-cre)L1Spo/0 mice (B, D, and E) P3 mouse brains with latex dye injected into the left ventricle of the heart. (D and E) Magnified views of blood vessels in the hippocampal area. (E) Asterisks indicate peculiar looping of vessels at the distal tips of arteries shunting to veins. A, artery; V, vein. (F-K) Vascular morphology of control (F, H, and J) and mutant (G, I, and K) P3 lungs. (F and G) Dissection microscopic view of pulmonary veins. Double-headed arrows indicate diameter of pulmonary veins. A dashed circle highlights the area of abnormal tangled vessels, and an arrow indicates looping of a dilated vessel (G). (H and I) Gross views of left lung after Evans blue dye injection via jugular veins. Note bumpy, dilated looping vessels in the mutant lungs (I). (J and K) Scanning electron microgram view of corrosion cast, showing lack of microvessels and presence of numerous dilated looping vessels (asterisks) in the mutant lungs (K). (L-Q) Gross views of small intestines of control (L, N, and P) and mutant (M, O, and Q) P3 mice. AV shunts and abnormal anastomosis was observed by latex dye (O) and corrosion cast (indicated by an arrow with asterisk; Q). Scale bars: 2 mm (A and B); 1 mm (C, D, H, I, and N-Q); 300 um (E); 500 um (F, G, L, and M).
Copyright This image is from Park SO, J Clin Invest 2009 Nov;119(11):3487-96 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:154620
Associated
Alleles
Symbol Name
Acvrl1tm2.1Spo activin A receptor, type II-like 1; targeted mutation 2.1, S Paul Oh
Tg(Acvrl1-cre)L1Spo transgene insertion L1, S Paul Oh
Associated
Genotypes
Allelic Composition Genetic Background
Acvrl1tm2.1Spo/Acvrl1tm2.1Spo
Tg(Acvrl1-cre)L1Spo/0
involves: 129 * FVB

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory