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| Caption | Externally visible phenotypes of Sh3pxd2bnee/Sh3pxd2bnee (nee) mice. Comparing littermate controls homozygous for wild-type (WT) alleles (left column) with mutant mice homozygous for the nee mutation (right column), mutants exhibit abnormal growth, craniofacial, and ocular phenotypes. a, b Homozygote mutants exhibit small body size, as is evident in this comparison of 4-month-old females. c, d Craniofacial abnormalities of mutants characterized by shortened noses and domed skulls. e-h Two different ophthalmic slit-lamp views of the same eyes from 1-month-old mice. Note that while WT mice have a clear cornea and normal anterior chamber depth (e), mutants have a cloudy cornea and enlarged anterior chamber (f, black double arrow). Viewed in this orientation, the normal mouse iris and cornea appear very close to one another, leaving little to no discernible depth to the anterior chamber. The irideocorneal angle of WT mice is characterized by a sharply defined limbus (g, arrowhead), whereas the irideocorneal angle of the mutant has severe peripheral anterior synechia (h, double arrow). | ||||
| Copyright | This image is from Mao M, Mamm Genome 2009 Aug;20(8):462-75 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:153369 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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