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| Caption | Whrntm1Tili/Whrntm1Tili (whirlin+/+) mice have morphological defects around the periciliary membrane complex (PMC) in photoreceptors revealed by electron microscopy. (A) A representative image showing the normal ultrastructure around the PMC in the wild-type (whirlin+/+) photoreceptor. (B-F) In mutant mice, abnormal distance (E) and membrane fusion (empty arrows, B-E) between the apical inner segment and the connecting cilium were found. In addition, a large amount of vacuoles (filled arrows, D-F) were accumulated around the PMC. (D,D9) show the same cell at different sectioning levels. OS, outer segments; CC, connecting cilia; IS, inner segments. Scale bars, 200 nm. (G) All the above abnormalities exist in a small fraction of photoreceptors randomly distributed in the retina of mutant mice. The number of mice analyzed in each group is indicated in the bottom of each bar. Mean +/- SEM; **p<0.01. | ||||
| Copyright | This image is from Yang J, PLoS Genet 2010;6(5):e1000955, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:160677 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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