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| Caption | Ultrastructural defects in the intestinal epithelium of Myo5btm1a(KOMP)Wtsi/Myo5btm1a(KOMP)Wtsi (KO) E20 embryos. (A) Transmission electron microscopy (TEM) micrograph showing microvillus inclusion bodies in mutant E20 embryos (scale bar 0.5 um). (B) Apical microvilli of enterocytes in wild-type (WT) and mutant E20 embryos (scale bar 0.5 um). MV: microvilli; White arrowheads: subapical microvesicles; asterisk indicates a subapical region devoid of microvesicles. (C) Average ( SEM) length of microvilli projecting into the lumen and actin rootlets. (D) Number of microvilli observed per micrometer in transverse sections of the brush border. The normal junction between enterocytes in WT E20 embryos is shown in (E). Scale bar 1 um. Microvilli-like structures could be observed in the lateral membrane of enterocytes in mutant mice (F). Scale bar 1 um. **p < 0.01 (Student's T-test). | ||||||
| Copyright | This image is from Carton-Garcia F, Sci Rep 2015;5():12312, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:229427 | ||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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