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Caption Premature differentiation within the prehypertrophic zone in the long bone growth plates in Flnbtm1Vshn/Flnbtm1Vshn (FlnB-/-) mice. (A) Col2a1 and Col10a1 double immunostaining on P1 null radius shows an abnormally increased region of overlapping expression for the proliferation and hypertrophic markers (open arrow). Quantitative analysis of the length of Col2a1+-Col10a1+ overlapping expression relative to the growth plate length. The Col2a1+-Col10a1+ overlapping region is increased in mutant mice at P1 and 2 week old age (17.7% vs 8.6%, 24.2% vs 19.1% in mutant and wild-type (WT), respectively). The ratio at P7 shows the similar, albeit not significant, trend of change. At P1, n samples = 6, for P7 and 2 week age, n samples = 3. (B) Pthr1 antibody immunostaining. Pthr1+ zones are thickened in the mutant radius at P1, P7 and 2 weeks. At 2 weeks, most of the chondrocytes become Pthr1+ in some mutant mice (open arrow). (C) Ihh antibody immunostaining. Ihh+ zones are thickened in the mutant radius at P1, P7 and 2 weeks. At 2 weeks, the Ihh+ zone covers both the prehypertrophic and hypertrophic zones in most of the mutant mice (open arrow). Scale bars = 200 um.
Copyright This image is from Hu J, PLoS One 2014;9(2):e89352, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:213355
Associated
Alleles
Symbol Name
Flnbtm1Vshn filamin, beta; targeted mutation 1, Volney Sheen
Associated
Genotypes
Allelic Composition Genetic Background
Flnbtm1Vshn/Flnbtm1Vshn involves: 129S6/SvEvTac * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory