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| Caption | Peripheral, but not central innervation is drastically reduced in Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo (TrkAC-KI) mice. (A-D) Peptidergic (CGRP-positive) and total (PGP9.5-positive) fiber innervation is decreased in thick glabrous skin of adult mutant hindlimbs. (E) Free nerve endings (FNE) counts in thick glabrous skin. Shown are means +/- s.e.m. from 8-10 sections from two animals per genotype (* p>0.05, ** p<0.01). (F-I) Peptidergic (CGRP-positive) and total (PGP9.5-positive) fiber innervation is decreased in thin glabrous skin of adult mutant hindlimbs. (J) FNE counts in thin glabrous skin. Shown are means +/- s.e.m. from 8-10 sections from two animals per genotype (* p>0.05, ** p<0.01). (K,L) Central projections are normal in mutant mice. Peptidergic (CGRP-positive, green) and nonpeptidergic (IB4-positive, red) fibers normally innervate adult spinal cord in mutant mice. Scale bar is 50 um. | ||||
| Copyright | This image is from Gorokhova S, PLoS Genet 2014 Feb;10(2):e1004081, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:210892 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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