Phenotype Image Detail

Image

Caption

Phenotypic characterization of Fkbp10^{tm2a(EUCOMM)Wtsi}/Fkbp10^{tm2a(EUCOMM)Wtsi} (-/-) embryos. (A) Mutant embryos (right) show growth delay compared with their wild-type (+/+) littermates (left) starting by E13.5. By E18.5, there is altered craniofacial shape and downward facing forelimbs (indicated with arrows). (B) Hematoxylin and eosin staining show no major defects in gross organ histology at E15.5. (C) Skeletal preparations at E17.5 show no skeletal patterning defects.

This image is from Lietman CD, Hum Mol Genet 2014 Sep 15;23(18):4822-31, an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License. J:213596

Associated
Alleles

Symbol	Name
Fkbp10^{tm2a(EUCOMM)Wtsi}	FK506 binding protein 10; targeted mutation 2a, Wellcome Trust Sanger Institute
Fkbp10^{tm2a(EUCOMM)Wtsi}	FK506 binding protein 10; targeted mutation 2a, Wellcome Trust Sanger Institute

Associated
Genotypes

Allelic Composition	Genetic Background
Fkbp10^{tm2a(EUCOMM)Wtsi}/Fkbp10^{tm2a(EUCOMM)Wtsi}	involves: C57BL/6J * C57BL/6N

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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