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Phenotype Image Detail
Caption Snx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Raba (Snx10 KD) and Tcirg1tm1Ypl/Tcirg1tm1Ypl (Atp6i KO) mice show a combined phenotype: osteopetrorickets. A) Radiographs (top and bottom panels) show that both mutant mice have bones with a higher radio-density and lack cortical bone. The metaphyseal fraying and cupping seen in the femur and tibia are features of rickets (bottom panels). B) MicroCT surface images of the femur show cortical bone deficiency, which produces a moth-eaten appearance and also confirms hypo-mineralization of condyles in both mutants. The white line in the longitudinal mid-plane sections (B, top) indicates the region where the transverse microCT images were taken (B, bottom).
Copyright This image is from Ye L, PLoS Genet 2015 Mar;11(3):e1005057, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:224711
Symbol Name
Snx10tm1a(EUCOMM)Raba sorting nexin 10; targeted mutation 1a, Ricardo A Battaglino
Tcirg1tm1Ypl T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3; targeted mutation 1, Yi Ping Li
Allelic Composition Genetic Background
Tcirg1tm1Ypl/Tcirg1tm1Ypl involves: 129S4/SvJae * C57BL/6J
Snx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Raba involves: 129S4/SvJae * C57BL/6 * C57BL/6J

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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