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| Caption | Spon1tm1Gdpa/Spon1tm1Gdpa (KO) mice exhibit post-natal accumulation of bone. (A) Wild-type (WT) and mutant skeletons were prepared from newborn (P0) littermates and stained with Alizarin Red/Alcian Blue to assess skeletal size and ossification. Right Panel: P0 tibiae were stained with H&E and the areas corresponding to the hypertrophic zone (HZ) and total growth plate (TGP) measured. Graph shows similar average HZ lengths in mutant and wild-type (WT) from 6 littermate pairs. (B) Safranin O/Fast Green staining of tibia and femur from 6 month old male mice. Panels below show Safranin-O/Fast Green staining articular cartilage from the medial tibial plateau of 6 month old male mice. Arrows denote areas of increased bone deposition in mutant mice. Graph indicates mean area of tibial articular cartilage (AC) and growth plate cartilage (GP) for 5 WT and KO mice; differences were not significant (P>=0.2). Scale bars; 200 um for knee sections and 100 um for articular cartilage. | ||||
| Copyright | This image is from Palmer GD, PLoS One 2014;9(5):e98388, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:214251 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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