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Phenotype Image Detail
Image
Caption Compound Wwtr1tm1.1Eno/Wwtr1tm1.1Eno Yap1tm1.1Eno/Yap1tm1.1Eno Tg(Myh6-cre)2182Mds/0 (Yap cKO; Taz cKO) mutants exhibit cardiac abnormalities and defects in proliferation and survival. (A) H&E-stained heart sections from control (Wwtr1tm1.1Eno/Wwtr1tm1.1Eno Yap1tm1.1Eno/Yap1tm1.1Eno) and Yap cKO; Taz cKO mice at P1. (Scale bar: 1 mm). (B) PH3-stained sections of hearts fromcontrol and Wwtr1tm1.1Eno/Wwtr1+ Yap1tm1.1Eno/Yap1tm1.1Eno Tg(Myh6-cre)2182Mds/0 (Yap cKO; Taz cHET) mice at P1. The green signal and white arrowsindicated PH3-positive staining, and the red signal indicates cTnT immunostaining. (Scale bar: 200 um.) (C) TUNEL stained sections of hearts from control and Yap cKO; Taz cHET mice at P4. The red signal and white arrows indicate TUNEL-positive staining. (Scale bar: 200 um.)
Copyright This image is from Xin M, Proc Natl Acad Sci U S A 2013 Aug 20;110(34):13839-44. Copyright 2013 National Academy of Sciences, U.S.A. J:200670
Associated
Alleles
Symbol Name
Tg(Myh6-cre)2182Mds transgene insertion 2182, Michael D Schneider
Wwtr1tm1.1Eno WW domain containing transcription regulator 1; targeted mutation 1.1, Eric N Olson
Yap1tm1.1Eno yes-associated protein 1; targeted mutation 1.1, Eric N Olson
Associated
Genotypes
Allelic Composition Genetic Background
Wwtr1tm1.1Eno/Wwtr1+
Yap1tm1.1Eno/Yap1tm1.1Eno
Tg(Myh6-cre)2182Mds/0 		involves: 129S/SvEv * FVB/N
Wwtr1tm1.1Eno/Wwtr1tm1.1Eno
Yap1tm1.1Eno/Yap1tm1.1Eno
Tg(Myh6-cre)2182Mds/0 		involves: 129S/SvEv * FVB/N
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory