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| Caption | Loss of Wasl leads to hypoplasia and loss of glomeruli and proximal tubules. (A-C) PAS staining (P0) of wild-type and Wasltm2Sbs/Wasltm2Sbs Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ (N-WaspCM-/-) kidneys showing hypoplasia in mutants. (D,E) Sections of P0 kidneys processed for Podocin analysis shows a strong decrease in glomeruli formation in mutant kidneys. Average count and standard deviation from four controls and four mutants are shown in F. ***p<0.0001. (G-I) Sections of P0 kidneys processed for LTL and Calbindin staining shows reduced proximal tubule formation in mutant kidneys. Scale bars represent 100 um (A-E), 100 um (G-I). | ||||||
| Copyright | This image is from Reginensi A, PLoS Genet 2013 Mar;9(3):e1003380, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195266 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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