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Phenotype Image Detail
Image
Caption Endogenous Gja3 influences cataract formation caused by the Gja8R205G mutation. (A) Lens photos of wild-type (Gja8+/+ Gja3+/+), Gja8R205G/Gja8+ (Gja8R205G/+Gja3+/+), Gja8R205G/Gja8R205G (Gja8R205G/R205GGja3+/+), and double mutant Gja8R205G/Gja8R205G Gja3tm1Scr/Gja3tm1Scr (Gja8R205G/R205GGja3-/-) mice at the age of 3 weeks. These mutant lines were bred into the C57BL/6J strain background. While the Gja8R205G/Gja8R205G lens revealed vacuole-like defects in the lens periphery (indicated by a white arrow), the double Gja8R205G/Gja8R205G Gja3tm1Scr/Gja3tm1Scr mutant lens showed a clear lens periphery (indicated by a white arrow). Scale bar, 1 mm. (B) Histological sections of Gja8R205G/Gja8R205G mutant and Gja8R205G/Gja8R205G Gja3tm1Scr/Gja3tm1Scr mutant lenses from 3-week-old littermates. The homozygous Gja8R205G/Gja8R205G lens section showed disorganized peripheral fibers with vacuoles or enlarged extracellular spaces (labeled with asterisk) near the lens bow region (indicated by an arrowhead), while the double Gja8R205G/Gja8R205G Gja3tm1Scr/Gja3tm1Scr mutant lens section shows organized and elongated periphery fiber cells at the bow region (indicated by an arrowhead). Scale bar, 50 um.
Copyright This image is from Xia CH, PLoS One 2012;7(12):e52894, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195727
Associated
Alleles
Symbol Name
Gja3tm1Scr gap junction protein, alpha 3; targeted mutation 1, The Scripps Research Institute
Gja8R205G gap junction protein, alpha 8; Arg205Gly
Associated
Genotypes
Allelic Composition Genetic Background
Gja8R205G/Gja8R205G B6.Cg-Gja8R205G
Gja3tm1Scr/Gja3tm1Scr
Gja8R205G/Gja8R205G
involves: 129S4/SvJae * CWD/LeAgl * SJL/J

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory