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| Caption | Scanning electron micrographs of cochlear sensory epithelium from Myo7a mutant strains at 8 weeks old. (A-C) Wild-type (Myo7a+/+), (D-F) Myo7aewaso/Myo7aewaso (Myo7aI487N/I487N) and (G-I) Myo7admbo2/Myo7admbo2 (Myo7aF947I/F947I) mice at the apical, middle and basal cochlear level. Signs of degeneration and/or misorientation of outer hair cell (OHC) bundles is evident in both Myo7aewaso/Myo7aewaso (D-F) and Myo7admbo2/Myo7admbo2 (G-I) mice at all levels of the cochlea. This appears to be more severe in Myo7aewaso/Myo7aewaso mutants, where many bundles are missing in the mid and basal regions (E and F). Inner hair cell (IHC) bundles are also affected, appearing disorganised and/or showing signs of fusion in the basal levels of Myo7aewaso/Myo7aewaso cochleae (asterisk in F), and conversely in the apical region of Myo7admbo2/Myo7admbo2 mutants (asterisk in G). Scale bar: 10 um (A-I). | ||||||
| Copyright | This image is from Miller KA, PLoS One 2012;7(12):e51284, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195666 | ||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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