| Image |
|
||||
| Caption | ABHD12 disruption causes age-dependent increases in microglial activation in the mouse brain. (A-C) Representative images of Iba1 immunostaining for microglia in the cerebellum of 18-month-old (A), 12-month-old (B), and 6-month-old (C) wild-type (ABHD12+/+) and Abhd12tm1Crv/Abhd12tm1Crv (ABHD12-/-) mice. (D-F) Quantifying the number of enlarged cells (>200 um2) revealed significantly more activated microglia in cerebellar sections from 18-month-old (D) and 12-month-old (E) mutant mice compared with wild-type mice. No genotype differences were observed at 6 months of age (F). Data represent the averages +/- SEM. ***P < 0.001 (n = 3-4 per genotype per age group). (Scale bar, 100 um.) | ||||
| Copyright | This image is from Blankman JL, Proc Natl Acad Sci U S A 2013 Jan 22;110(4):1500-5. Copyright 2013 National Academy of Sciences, U.S.A. J:193716 | ||||
|
Associated Alleles |
|
||||
|
Associated Genotypes |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/30/2024 MGI 6.23 |
|
|
|
||
Analysis Tools