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| Caption | Skeletogenesis is severely impaired in Apctm1Rsmi/Apctm1Rsmi Tg(Col2a1-cre)1Rsjo/0 (Col2a1-cre;Apc15lox/15lox) mice. (A-E) Greatly impaired skeletal development and growth arrest of mutant embryos. Gross appearance (A-C) and Alcian blue and Alizarin red staining (D-E) of skeletal preparations of mutant embryos and control littermates at indicated developmental stages. Conditional Apc mutants showed lack of mandible outgrowth (arrowheads), poor limb development (black arrows), and an open thoracic and abdominal cavity (red arrows). Scale bars: 1 mm. | ||||||
| Copyright | This image is from Miclea RL, BMC Dev Biol 2009;9():26, an open-access article, licensee BioMed Central Ltd. J:149225 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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