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| Caption | Phenotype of Porcntm1.1Vdv/Y Tg(Prrx1-cre)1Cjt/0 (PrxcKO) mice. (A) Shortened forelimbs at E18.5 in mutants compared to wild-type littermate (control). (B) Stunted growth at day 7 (P7) in PrxcKO compared to control littermate. (C) Appearance of PrxcKO compared to WT littermate at P28. (D) Digital abnormalities showing shortened limbs and shortened digits in PrxcKO compared to WT. F, forelimb; H, hindlimb. (E) Whole-skeleton preparations of newborn mice (NB). Mutant exhibits shortening of all skeletal elements. (F, G) Skeletal preparations of NB forelimbs and hindlimbs. (H) Whole-skeleton preparations of P28 mice. Mutant exhibits more dramatic shortening of all skeletal elements. (I, J) Skeletal preparations of forelimbs (F) and hindlimbs (H) at P28. hu, humerus; ra, radius; sc, scapula; ul, ulna; cl, clavicle; il, ilium; pu, pubis; fe, femur; ti, tibia; fi, fibula. | ||||||
| Copyright | This image is from Liu W, PLoS One 2012;7(3):e32331, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:186934 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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