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| Caption | Gata4tm1Grg/Gata4tm1Grg mice display growth retardation and a thin myocardium. Right (A,D,G), left (B,E,H) and frontal (C,F,I) views of embryos are shown. Growth retardation of Gata4tm1Grg/Gata4tm1Grg (Gata4 G295Ski/ki) E9.5 embryos (G,H) when compared to wild-type (A,B) and heterozygote (Gata4 G295Ski/wt) littermates (D,E). A fused heart tube with proper looping is found in homozygous mutant embryos (I) simlar to wild-type (C) and heterozygous (F) littermates. Coronal sections through heterozygous (J,K) and homozygous (L,M) embryos at E9.5 (J,L) and E10.5 (K,M). Normal myocardial thickness is found at E9.5 in homozygous mutant embryos (L) while thin myocardium is seen at E10.5 (M) when compared to heterozygote littermate (K). Quantification of ventricular wall thickness in heterozygous and homozygous embryos at E9.5 (N) and 10.5 (O). RV, right ventricle; LV, left ventricle; red arrow, heart; A, atria; V, ventricle; OFT, outflow tract. Scale bars indicate 200 um. | ||||
| Copyright | This image is from Misra C, PLoS Genet 2012 May;8(5):e1002690, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:185124 | ||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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