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Phenotype Image Detail
Image
Caption Aortas from wild-type (Asef +/+) and Arhgef4tm1Taki/Arhgef4tm1Taki (Asef -/-) mice were embedded in Matrigel and cultured for 8 days in the presence of bFGF, EGF, VEGF, IGF-1, and 2% serum. The regions in boxes are shown magnified. Magnification X 40 (upper panels), X 100 (lower panels). The graph shows the number of endothelial cell sprouts per aortic ring at day 8. Open bars, wild-type; filled bars, Arhgef4tm1Taki/Arhgef4tm1Taki mice. Results are expressed as the mean +/-S.E. of three independent experiments. *, p<0.05. Scale bar, 100 um.
Copyright This image is from Kawasaki Y, J Biol Chem 2010 Jan 8;285(2):1199-207 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:159959
Associated
Alleles
Symbol Name
Arhgef4tm1Taki Rho guanine nucleotide exchange factor 4; targeted mutation 1, Tetsu Akiyama
Associated
Genotypes
Allelic Composition Genetic Background
Arhgef4tm1Taki/Arhgef4tm1Taki involves: C57BL/6 * C57BL/6J * CBA

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory