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| Caption | Prolonged and more severe neurological deficits after spreading depression in mutant mice. Representative photographs demonstrating the wire grip and neurological deficits after a single spreading depression (SD) in female wild-type (WT) and homozygous Cacna1atm1Maag/Cacna1atm1Maag (R192Q) and Cacna1atm3Maag/Cacna1atm3Maag (S218L) mice. In wire grip test, WT mice showed minimal deficits soon after SD (a), while Cacna1atm3Maag/Cacna1atm3Maag mice continued to fall off the wire for prolonged periods (b). Neurological examination showed leaning (c) and circling (d) in Cacna1atm1Maag/Cacna1atm1Maag and Cacna1atm3Maag/Cacna1atm3Maag mice. SD was evoked in the right hemisphere in all mice. (e) Graphs showing the time course of neurological deficits (only wire grip latency shown) from four representative knockin mice. One or more episodes of transient neurological deterioration (red arrows) were observed after full or partial recovery in 7/7 homozygous female Cacna1atm1Maag/Cacna1atm1Maag knockin, 4/6 homozygous male Cacna1atm1Maag/Cacna1atm1Maag knockin, 3/3 homozygous female Cacna1atm3Maag/Cacna1atm1Maag knockin, and 4/5 heterozygous female Cacna1atm3Maag/Cacna1a+ knockin mice. Vertical dashed line indicates a non-fatal generalized seizure that occurred shortly after the 40 min assessment time point. | ||||||
| Copyright | This image is from Eikermann-Haerter K, J Clin Invest 2009 Jan;119(1):99-109 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:144701 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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