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| Caption | Clinical ocular phenotype comparison of wild-type and Pax2M1Bpb/Pax2+ mice. (A) Fundus photograph of wild-type C57BL/6 mouse showing normal optic nerve and radial pattern of blood vessels. (B) Fundus photograph of Pax2M1Bpb/Pax2+ mouse showing congenital excavation of the optic nerve head with peripapillary pigment changes (arrow). (C) Lectin immunofluorescence of wild-type mouse showing normal, radial vessel patterning. (D,E) Lectin immunofluorescence of mutant mice showing abnormal vascualr patterning, including curving vessels towards the dorsal retina (D, arrows, d= dorsal, v= ventral) and separation of the central retinal vascular trunks (E, arrows). Histologic section of a wild-type (F) and a mutant (G) mouse eye through the optic nerve and peripapillary retina showing abnormal excavation of the optic nerve (G, arrow) and retinal rosette formation (G, arrowhead). Remnants of the tunica vasculosis lentis and mild extension of the retinal pigment epithelium were variably noted in histopathology from the mutant eyes (data not shown). | ||||
| Copyright | This image is from Alur RP, PLoS Genet 2010;6(3):e1000870, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:159240 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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