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Phenotype Image Detail
Image
Caption The muscle weakness phenotype of Fbn2mz/Fbn2mz mice. The original pedigree in which the Fbn2mz/Fbn2mz (Mz/Mz) mutant was identified. (B) Grip-strength comparison using 3-month old mutants (n=30) and wild-type (+/+) (n=26) littermates. The average force generated by wild-type mice has been set as 100%. Mean and SD are shown. The differences are highly significant; P-values (Student's test): *** P<0.0001. (C) Close-up photos showing the different grasp of mutants and wild-type littermates. (D) Example of clasping phenotype observed in mutants and wild-type littermates. (E) A wire manoeuvre test of mutant and wild-type littermates. Scores as as follows: 0 = mouse swings hindlegs on to bar and makes way to edge rapidly; 1 = mouse swing hindlegs on to bar after a delay and makes way to edge rapidly; 2 = mouse is suspended by using underarms to straddle bar and does not lift hind limbs, eventually falls; 3 = mouse falls after short delay; 4 = mouse fall immediately.
Copyright This image is from Miller G, PLoS One 2010;5(2):e9137, an open-access article distributed under the terms of the Creative Commons Attribution License. J:157998
Associated
Alleles
Symbol Name
Fbn2mz fibrillin 2; mariusz
Associated
Genotypes
Allelic Composition Genetic Background
Fbn2mz/Fbn2mz involves: BALB/cAnNCrl * C3H/HeH

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory