About   Help   FAQ
Phenotype Image Detail
Image
Caption A and B: Scanning electron micrographs of E18.5 wild-type and Fras1tm1Chpk/Fras1tm1Chpk (Fras1-/-) lungs. A: Whole lung of a wild-type embryo displaying complete septation of right lung lobes (arrowheads). B: Fused medial and caudal lobes in the right lung of mutant embryos (arrowhead). C and D: Hematoxylin and eosin staining of lung sections from E16.5 wild-type and mutant lungs. C: A wild-type control displaying the normal four-lobed pattern of the right lung. D: Mutants usually exhibit complete fusion of the medial and caudal lobes of the right lung, whereas the cranial lobe is partially separated (arrowheads). E and F: Whole lungs of wild-type and mutant embryos at E12.5. Lungs of mutant embryos (F) exhibit the same extent of epithelial branching as wild-type controls (E). Abbreviations: al, accessory lobe; cal, caudal lobe; crl, cranial lobe; e, airway epithelia; le, left lung; ml, medial lobe. Scale bar: A and B, 400 um; C and D, 10 um.
Copyright This image is from Petrou P, J Biol Chem 2005 Mar 18;280(11):10350-6 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:137010
Associated
Alleles
Symbol Name
Fras1tm1Chpk Fraser extracellular matrix complex subunit 1; targeted mutation 1, George Chalepakis
Associated
Genotypes
Allelic Composition Genetic Background
Fras1tm1Chpk/Fras1tm1Chpk involves: 129S1/Sv * 129X1/SvJ * NMRI

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2019
MGI 6.14
The Jackson Laboratory