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| Caption | Phenotype of Fbxw7tm1Kin/Fbxw7tm1Kin embryos. A-C: Gross appearance of wild-type (Fbw7+/+, A) and Fbxw7tm1Kin/Fbxw7tm1Kin (Fbw7-/-, B and C) embryos at E10.5. Arrows in B and C indicate hemorrhage in the head region. D-G: Whole mount immunohistochemical analysis with anti-PECAM-1 of the head region (D and E) and yolk sac (F and G) of E10.5 embryos. Mutant embryos (E and G) exhibited a disorganized vasculature compared with the fine vascular network of wild-type embryos (D and F). Arrows and arrowhead in D indicate head veins and the internal carotid artery, respectively. H and I: Immunohistochemical staining with anti-PECAM-1 of wild-type (H) and mutant (I) embryos at E9.5. Arrowheads in I indicate the absence of anterior cardinal veins in mutant embryos. Abbreviations: nt, neural tube; acv, anterior cardinal vein; da, dorsal aorta; at, atrium. Scale bars: A-C, F and G, 500um; D and E, 250um; H and I, 100um. | ||||
| Copyright | This image is from Tsunematsu R, J Biol Chem 2004 Mar 5;279(10):9417-23 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:88517 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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