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Phenotype Image Detail
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Caption A: Vibratone sections were prepared from cerebella of Nrcamtm1Gmt/Nrcamtm1Gmt L1camtm1Sor/Y (Nr-/-L1-/y) mouse and its littermate. Top panels are P6 cerebella stained with cresyl violet. Some fissures are missing or less well developed in double mutant mice compared with littermates. Note that although the size of cerebellum is smaller in the double mutant mouse, the size of the brain stem is similar to that of littermate controls. Bottom panels are magnified views of top panels. Note that in comparable regions within the folia, the IGL is thinner in the double mutant than in the littermate control (arrows). Bars, 640um (top) and 160um (bottom). B: Frontal vibratone sections were prepared from brain of double mutant mouse and its littermate at P5. Top and middle panels were stained with antineurofilament antibody following Nissl staining. Magnified views of hippocampal regions of top panels are shown in the middle panels. Although brain size is smaller, overall structures including hippocampus are similar between the double mutant mouse and their littermate. Bottom panels show layer formation in cortex of double mutant mouse and its littermate visualized by Nissl staining on vibratone sections. Layer formation in cortex appears normal in double mutant mice. Bar: (top) 400um; (others) 200um.
Copyright This image is from Sakurai T, J Cell Biol 2001 Sep 17;154(6):1259-73, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:71828
Associated
Alleles
Symbol Name
L1camtm1Sor L1 cell adhesion molecule; targeted mutation 1, Philippe Soriano
Nrcamtm1Gmt neuronal cell adhesion molecule; targeted mutation 1, Martin Grumet
Associated
Genotypes
Allelic Composition Genetic Background
L1camtm1Sor/Y
Nrcamtm1Gmt/Nrcamtm1Gmt
involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster

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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory