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Phenotype Image Detail
Caption Liver histology. A: Hematoxylin and eosin stained liver section of a Fahtm1Mgo/Fahtm1Mgo mouse showing pathology typical of hereditary tyrosinemia type 1 (HT1), with many imflammatory cells (black arrow), necrotic cells (white arrow), and disorganized liver architecture, compared with (B) Hematoxylin and eosin staining for a Fahtm1Mgo/Fahtm1Mgo Hgdaku/Hgdaku mouse 4 weeks off 2-(2-nitro-4-trifluro-methylbenzoyl)-1-3-cyclohexanedione (NTCB) showing normal liver cells, with organized columnar appearance of hepatocytes. C: Hematoxylin and eosin staining of double mutant mouse >1 year off NTBC also demonstrating normal liver histology. D: Hematoxylin and eosin staining of Fahtm1Mgo/Fahtm1Mgo Hgdaku/Hgd+, depicting nodules (black arrows) of healthy hepatocytes against a background of sick cells. Nodules were depleted of glycogen (PAS staining) (E), negative for alpha-fetoprotein (F), and contained many cells positive for Ki67 (G) whereas wild type cells did not (H).
Copyright This image is from Manning K, Proc Natl Acad Sci U S A 1999 Oct 12;96(21):11928-33. Copyright 1999 National Academy of Sciences, U.S.A. J:77295
Symbol Name
Fahtm1Mgo fumarylacetoacetate hydrolase; targeted mutation 1, Markus Grompe
Hgdaku homogentisate 1, 2-dioxygenase; alkaptonuria
Allelic Composition Genetic Background
involves: 129S7/SvEvBrd * NB
involves: 129S7/SvEvBrd * NB
Fahtm1Mgo/Fahtm1Mgo involves: 129S7/SvEvBrd * PT

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