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Phenotype Image Detail
Image
Caption Right subclavian artery moprhology. C-E: Transverse sections through the hearts of E14.5 wild type (C), Vangl2Lp/Vangl2Lp (D), and Vangl1Gt(XL802)Byg/Vangl1+ Vangl2Lp/Vangl2+ (E) embryos. In wild type embryos (C), the right subclavian artery (arrows) is positioned laterally from trachea and esophagus. In homozygous (D) and double heterozygous (E) embryos, the right subclavian artery is positioned dorsal to the esophagus. F and G: Three-dimensional reconstruction of the arteries of E14.5 wild type (F) and double mutant hearts (G). Ao, aorta; DAo, dorsal aorta; E, esophagus; LV, left ventricle; PAA, pharyngeal arch artery; PV, pulmonary valve; RA, right atrium; rsca, right subclavian artery; RV, right ventricle; T, trachea; TH, thymic. Magnification x200.
Copyright This image is from Torban E, Proc Natl Acad Sci U S A 2008 Mar 4;105(9):3449-54. Copyright 2008 National Academy of Sciences, U.S.A. J:132697
Associated
Alleles
Symbol Name
Vangl1Gt(XL802)Byg VANGL planar cell polarity 1; gene trap XL802, BayGenomics
Vangl2Lp VANGL planar cell polarity 2; loop tail
Associated
Genotypes
Allelic Composition Genetic Background
Vangl2Lp/Vangl2Lp LPT/LeJ
Vangl1Gt(XL802)Byg/Vangl1+
Vangl2Lp/Vangl2+
involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory