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Phenotype Image Detail
Image
Caption Engtm1Mle/Eng+ (End +/-, Left) and Engtm1Mle/Engtm1Mle (End -/-, Right) embryos. Beta-gal expression driven by the Eng promoter was analyzed in whole heterozygous and homozygous embryos. At E9.0, embryos are of a similar size and their vasculature appears normal. The homozygous embryo shows an enlarged heart protruding forward (arrowhead). At E9.5, edematous pericardium (arrowhead) is observed in the homozygous embryo, which is growth-retarded compared with the heterozygote. At E10.5, the homozygous embryo is dead and is much smaller than the heterozygous embryo. Scale bar, 500um.
Copyright This image is from Bourdeau A, J Clin Invest 1999 Nov;104(10):1343-51 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:58502
Associated
Alleles
Symbol Name
Engtm1Mle endoglin; targeted mutation 1, Michelle Letarte
Associated
Genotypes
Allelic Composition Genetic Background
Engtm1Mle/Engtm1Mle involves: 129P2/OlaHsd * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory