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Phenotype Image Detail
Image
Caption Histology of age-dependent lipid storage in liver and small intestine and age-dependent white adipose tissue (WAT) disappearance in Lipatm1Ggb/Lipatm1Ggb mice. Hematoxylin/eosin (H&E) staining of paraffin-embedded sections from liver, small intestine, and skin from the back of an 8-month wild type (+/+) mouse, and a 1.5-month, 5-month, and 8-month Lipatm1Ggb/Lipatm1Ggb (-/-) mouse, as indicated. Notice that the lipids are mainly stored in hepatocytes in younger mice (1.5 months) and then in nonhepatocytes at the age of 5 and 8 months. The lipid accumulation in lamina propria is more significant at 5 months in the mutant mouse. At 8 months, the villi are swollen and full of lipid. Notice that the subcutaneous white adipose tissue are present in the younger mutant mouse, decrease significantly at 5 months, and completely disappear at 8 months. H&E staining of the enlarged lymph node (A), spleen (B), lung (C), and oil red O (ORO) staining of choroid plexus (D) from a 6-month mutant mouse.
Copyright This image is from Du H, J Lipid Res 2001 Apr;42(4):489-500 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text is from JLR. J:68812
Associated
Alleles
Symbol Name
Lipatm1Ggb lysosomal acid lipase A; targeted mutation 1, Gregory A Grabowski
Associated
Genotypes
Allelic Composition Genetic Background
Lipatm1Ggb/Lipatm1Ggb involves: 129P2/OlaHsd * CF-1

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/09/2022
MGI 6.21
The Jackson Laboratory