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Phenotype Image Detail
Image
Caption Histopathology in the kidney of Nos1tm1Plh/Nos1tm1Plh Nos2tm1Mrl/Nos2tm1Mrl Nos3tm1Plh/Nos3tm1Plh (n/i/eNOS-/-) and wild type (C57BL/6) mice. A: Renal tubular apoptosis (arrows) and regeneration (increased cell number) in mutant mice. H&E, hematoxylin and eosin staining. B: Renal glomerulosclerosis (hyalinization, pink color) in mutant mice. PAS, periodic acid-Schiff staining. C: Renal glomerular thrombi (arrows, dark blue) in mutant mice. PTAH, phosphotungstic acid-hematoxylin staining. Scale bars: 10um.
Copyright This image is from Morishita T, Proc Natl Acad Sci U S A 2005 Jul 26;102(30):10616-21. Copyright 2005 National Academy of Sciences, U.S.A. J:100308
Associated
Alleles
Symbol Name
Nos1tm1Plh nitric oxide synthase 1, neuronal; targeted mutation 1, Paul L Huang
Nos2tm1Mrl nitric oxide synthase 2, inducible; targeted mutation 1, John S Mudgett
Nos3tm1Plh nitric oxide synthase 3, endothelial cell; targeted mutation 1, Paul L Huang
Associated
Genotypes
Allelic Composition Genetic Background
Nos1tm1Plh/Nos1tm1Plh
Nos2tm1Mrl/Nos2tm1Mrl
Nos3tm1Plh/Nos3tm1Plh
involves: 129S4/SvJae * 129S7/SvEvBrd

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory