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Phenotype Image Detail
Image
Caption Panel A shows the size and general morphology of wild type (left) and Dhcr7tm1Gst/Dhcr7tm1Gst (right) embryos at E10.5, without significant difference. At P0, the mutant pups are significantly smaller and appear hypoxic (panel B). Panel C shows dorsal views of lungs from mutant (right) and wild type (left) at E13.5 and Panel D those at P0. Cross-sectional examination at the cardiopulmonary level at E20.5 (prior to birth) shows normal lobar septation, but lungs from mutant mice are smaller in size and have less distal sac space (cf. Panels E & F). Original magnification: Panels A & C 2x; Panels B & D, 0.7x; Panels E & F, 2x. Abbreviations: r, right; l, left; b, bronchial; br, bronchiole; e, esophagus; pa, pulmonary artery; ra, right atrium; la, left atrium; rv, right ventricle; lv, left ventricle.
Copyright This image is from Yu H, BMC Dev Biol 2004 Mar 2;4(1):1, an open-access article, licensee BioMed Central Ltd. J:93296
Associated
Alleles
Symbol Name
Dhcr7tm1Gst 7-dehydrocholesterol reductase; targeted mutation 1, G S Tint
Associated
Genotypes
Allelic Composition Genetic Background
Dhcr7tm1Gst/Dhcr7tm1Gst B6.129P2-Dhcr7tm1Gst

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory