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Phenotype Image Detail
Image
Caption A: Itgb2tm1Bay/Itgb2tm1Bay mouse on PL/J background (right) showing mild erythema and alopecia in the facial area; an Itgb2tm1Bay/Itgb2+ mouse (left). B: Severe dermatitis with progressive alopecia, severe erythema, scales and crusts. C: Histology of normal mouse skin. Note that the epidermis (e) consists of two or three cell layers. Embedded in the dermis (d) are hair follicles (h) and sebaceous glands (s). D: Histology of diseased skin showing hyperplasia of the epidermis subcorneal microabscesses (*), and hyperorthokeratosis (arrow). In the dermis, a diffuse inflammatory cell infiltrate is observed. E: Higher magnification of D showing granulocytes within a microabcess. F: Higher magnification of D. Note the hyperorthokeratosis and dilated capillaries in the dermis (arrow). Magnification: C & D, x100; E & F, x400.
Copyright This image is from Bullard DC, Proc Natl Acad Sci U S A 1996 Mar 5;93(5):2116-21. Copyright 1996 National Academy of Sciences, U.S.A. J:32126
Associated
Alleles
Symbol Name
Itgb2tm1Bay integrin beta 2; targeted mutation 1, Baylor College of Medicine
Associated
Genotypes
Allelic Composition Genetic Background
Itgb2tm1Bay/Itgb2tm1Bay involves: 129S7/SvEvBrd * PL/J

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory