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Phenotype Image Detail
Image
Caption (B-E) Five week old control (B & D) and Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr Tg(Gdf5-cre-ALPP)1Kng/0 (C & E) mice stained with Alcian blue to mark cartilage and alzarian red to mark bone. (B) Ankle of the control mouse with strong blue staining lining each joint (arrowheads). (C) Ankle of mutant mouse showing an absence of blue staining in most regions (arrowheads) and a joint fusion between the central (c) and second (2) tarsals (arrow). (D) Control and (E) mutant metatarsal/phalangeal joint which lacks blue staining in articular regions (arrowheads) but retains staining in the growth plate (asterisks). (F) Control forelimb. (G) Mutant forelimb with webbing between the first and second digit (black arrowhead).
Copyright This image is from Rountree RB, PLoS Biol 2004 Nov;2(11):e355, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:97780
Associated
Alleles
Symbol Name
Bmpr1atm2.1Bhr bone morphogenetic protein receptor, type 1A; targeted mutation 2.1, Richard R Behringer
Bmpr1atm2.2Bhr bone morphogenetic protein receptor, type 1A; targeted mutation 2.2, Richard R Behringer
Tg(Gdf5-cre-ALPP)1Kng transgene insertion 1, David M Kingsley
Associated
Genotypes
Allelic Composition Genetic Background
Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr
Tg(Gdf5-cre-ALPP)1Kng/0
involves: 129 * C57BL/6 * FVB/N-Tg(Gdf5-cre-ALPP)1Kng

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory