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Phenotype Image Detail
Image
Caption Homozygous Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor embryos are smaller than Chd7Gt(S20-7E1)Sor/Chd7+ and wild type embryos. Coronal sections of E10.5 wild type (A-D), Chd7Gt(S20-7E1)Sor/Chd7+ (E-H) and Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor (I-L) embryos stained with hematoxylin and eosin. Homozygous mutant embryos exhibit reduced thickness of the neuropithelium in the telencephalon (tel), midbrain (mb) and spinal cord (sc). The olfactory pit (op), optic eminence (oe), trigeminal ganglion (Vg) and hindlimbs (hl) are hypoplastic in homozygous mutants. Both heterozygous and homozygous mutants have delayed turning. The homozygous mutant otocyst (ot) is thickened and small. Fag, facio-acoustic VII-VIII preganglion; mp, mandibular prominence; aor, aorta; hrt, heart; rp, Rathke's pouch.
Copyright This image is from Hurd EA, Mamm Genome 2007 Feb;18(2):94-104 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:119812
Associated
Alleles
Symbol Name
Chd7Gt(S20-7E1)Sor chromodomain helicase DNA binding protein 7; gene trap S20-7E1, Philippe Soriano
Associated
Genotypes
Allelic Composition Genetic Background
Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
Chd7Gt(S20-7E1)Sor/Chd7+ involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory